Fantastic stay in a fantastic establishment. Andrea is the perfect host and Sara very helpful and pleasant too.
As for Quiriti Vatican Relais itself the location is great- Andrea will show you a couple of walks of Rome you can take and you really get to see the sites if you do follow them.
Rooms are clean and comfortable- the beds really have a great mixture of support and softness so a good night sleep is highly likely. Then to be woken by the local church bells in the morning gets you in the right mode for Rome. Breakfast room is also great so you can grab a coffee or three plus several types of flavoured yogurts,fruits,cheese,milk,chilled water bottles,pastries,bread etc etc Really handy and convenient to grab something before setting off for the day.
We did the early morning (arrive just after 7am) Sistine Chapel/Vatican tour so this hotel is perfect for that..go out and turn left then first right or right and turn first left and follow the road to the Vatican- about 10 mins brisk walk.
Also you can walk to Castel Sant'Angelo in 5/10 mins and then over the Ponte Sant'Angelo into the old town- you know the old town with the Pantheon,Trevi Fountain etc etc etc etc. Great location but not one i first thought of staying in but it really is a great location. From the local subway station (Lepanto) you can go to Termini in a few stops too.
If you can then stay here. We know if/when we ever go back to Rome again this is the top of our list of places to stay.